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Pathophysiology of Gastricacid Stimulation

  • Date Submitted: 08/07/2016 08:50 AM
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Pathophysiology of Gastric Acid Stimulation and Production
The gastrointestinal tract is inclusive of the mouth, pharynx, esophagus and stomach, the large and small intestines. The stomach, which is a saclike organ, functions to organize food for digestion and absorption by the intestines; the production of acids, to aid in the digestive process, is essential because acids immerse food bolus that is stored in the stomach, thus facilitating dejection. Normal gastric acid stimulation and production are essential to the efficient functioning of the digestive system (Lowry, Bhakta, & Nag, 2011). Changes in normal gastric acid stimulation and production result in Gastroesophageal reflux disease (GERD), peptic ulcer diseases (PUD) or gastritis. The purpose of this assignment is to describe the normal pathophysiology of gastric acid stimulation, describe how gastric acid stimulation is affected by GERD, PUD, explain how a selected patient factor impacts the pathophysiology of GERD,PUD and gastritis, describe diagnosis and treatment based on selected factor, and construct mind maps for both GERD, PUD and gastritis.
Normal Pathophysiology of Gastric Acid Production and Stimulation
The parietal cells, located on the walls of the stomach, functions to produce gastric acid, which is essential in the digestive process. A region within the parietal cells, the secretory canaliculus is regarded as the most acidic environ in the body (pH=8); it is from this area that gastric juice is released into the lumen. Gastric juices is secreted into the lumen in reaction to information received from the various paracrine, hormonal and neurocrine feedbacks (Huether & McCance, 2014). One of the primary hormonal activators for the production of gastric acid is gastrin. Gastrin is produced by G cells, found in the pyloric mucosa of the stomach (Borelli, 2011).
The stimulation of parietal cells by the various hormonal inputs, causes the secretion of hydrogen ions into the gastric...


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