Antibiotic

When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.ijidonline.com/

Final Abstract Number: 23.001 Session: Antibiotic Resistance Gram-Negative Date: Wednesday, March 10, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation Clinico epidemiologic and molecular characterization of metallo beta lactamases (MBLs) producing nosocomial Pseudomonas aeruginosa (PSA) 1 2 3 1 1 S. Chatterjee , A. Kumar , K. N. prasad , D. Mathai , A. Manoharan 1 2 Christian Medical College and Hospital, Vellore, Tamil Nadu, India, Amrita Institute of Medical 3 Science, Kochi, India, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India Background: The high prevalence of co-resistance to betalactam, aminoglycoside and quinolone against PSA has necessitated increased use of carbapenems. MBL production among PSA is one of the several mechanisms causing carbapenem resistance (CARB-R) transferable by integrons. We surveyed MBL production among PSA isolates collected via multicentric surveillance study. Methods: During March-September 2009 BMPLIII received 75 consecutively collected PSA causing infections of (skin and soft tissue-48, blood and respiratory tract 11 each, and other sites, 5) from four (50-AIMS,Kochi, 21-SGPGIMS, 2-MGIMS,2-AIIMS,Delhi) Indian Medical centers. Antimicrobial susceptibility testing by Kirby Bauer method against ceftazidime (CZD), cefepime(FEP), piperacillin/tazobactam (TZP), ticarcillin /clavulanic acid (TIM), gentamicin (GEN), amikacin(AK), ciprofloxacin(CIP), imipenem(IMP), meropenem(MEM), aztreonam(ATM) and colistin(CL) was done. MBL was screened by the Combined Disk Diffusion Test (CDDT) method using 0.5M EDTA (930 g) as the inhibitor...