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Global L-Serine Market Projected to Grow at a Cagr of 5.8% Within Expectations

  • Date Submitted: 09/01/2016 11:16 PM
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Global L-serine Market Projected To Grow At A CAGR Of 5.8% Within
Date: 2016-09-01
L-Serine is classified as a nutritionally non-essential amino acid. While the main source of
essential amino acids is from the diet, non-essential amino acids are normally synthesize by
humans and other mammals from common intermediates. As shown below, L-serine is
biosynthesized from a glycolytic intermediate, 3-phosphoglycerate (3-PG), in a three-step
process involving the enzymes: 3-phosphoglycerate dehydrogenase (3-PGDH), phosphoserine
aminotransferase (PSAT), and phosphoserine phosphatase (PSP).
L-Serine can also be derived in a reversible reaction from glycine; through degradation of protein
and phospholipids; and through dietary intake. The primary pathway maintaining adequate
serine concentrations is likely to depend on tissue type and stage of development.
L-Serine plays a role in cell growth and development (cellular proliferation). The conversion of
L-serine to glycine by serine hydroxymethyltransferase results in the formation of the
one-carbon units necessary for the synthesis of the purine bases, adenine and guanine. These
bases when linked to the phosphate ester of pentose sugars are essential components of DNA
and RNA and the end products of energy producing metabolic pathways, ATP and GTP. In
addition, L-serine conversion to glycine via this same enzyme provides the one-carbon units
necessary for production of the pyrimidine nucleotide, deoxythymidine monophosphate, also an
essential component of DNA.
L-Serine deficiency is a rare, inherited, metabolic disorder of L-serine biosynthesis. The majority
of the cases reported in the literature so far show a decrease in 3-phosphoglycerate
dehydrogenase (3-PGDH) activity resulting in low fasting serum and CSF L-serine levels.
Children with L-serine deficiency present with congenital microcephaly, then go on to develop
severe psychomotor retardation and intractable seizures.


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