Sbp in Liver Cirrhosis

ABSTRACT

Introduction

      Spontaneous bacterial peritonitis is a serious event in patients with liver cirrhosis and associated with significant morbidity and mortality. There are three forms of SBP i.e. culture negative neutrocytic ascites, monomicrobial non-neutrocytic bacterascites and polymicrobial bacterascites. Most common causative organisms of SBP are E. coli, streptococcus pneumonia and klebsiella. It can present in various ways like abdominal pain, increase in abdominal distension, fever, and encephalopathy or even with gastroenteritis. Liver cirrhosis has multifactorial etiology and most common causes in our country are hepatitis C and hepatitis B. Etiology of liver cirrhosis varies widely between different geographical areas of the world.
OBJECTIVES OF THE STUDY
      The objectives of study were to observe the culture and sensitivity pattern of ascitic fluid in patients with liver cirrhosis and to examine the resistance against various antibiotics.
STUDY DESIGN
      Descriptive study
SETTING
      Department of Gastroenterology - Hepatology in collaboration with Department of Microbiology of Shaikh Zayed Hospital Lahore
DURATION OF STUDY
      Six month from the date of acceptance of synopsis.
SAMPLE SIZE
      80 patients of liver cirrhosis with ascites
SAMPLING TECHNIQUE
      Non probability purposive technique
DATA COLLECTION PROCEDURE
      Eighty patients with liver cirrhosis and ascites diagnosed on the basis of history, physical examination and analysis of ascitic fluid were included in the study. Atleast 10 milliliter of ascitic fluid in 20 milliliter syringe with 16G needle was drawn in blood culture bottle and sent to microbiology laboratory for culture and sensitivity and record of resistance and sensitivity against various antibiotics conventionally and less commonly used to treat SBP.
RESULUTS
A total of 80 patients were included in the study. It included 41 (51%) male patients and 39 (49%) female patients....